vinorelbine – Navelbine and the patient – Adverse effects and what to do ? Navelbine Oral Navelbine IV

Navelbine ® IV & Navelbine ® Oral - Vinorelbine

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ADVERSE EFFECTS	HOW DO I KNOW?	CHRONOLOGY	WHAT MUST I DO?
Fever or infection (due to neutropenia, i.e. decreased white blood cells)	fever >38°C other symptoms: shivers, cough, thorethroat, infected, wound, frequency or pain when passing urine, ect.	Risk highest after 7 to 10 days after administration Back to normal within 4 to 5 days	Your doctor has your blood count checked (particulary polynuclear neutrophils) prior to each administration. If you have fever or any of the other symptoms, call your doctor with no delay.
Fatigue (due to anaemia, i.e. decreased haemoglobin in the blood).	loss of energy, of strength difficulty in achieving tasks that used to be easier	May happen during treatment	Your doctor may have your haemoglobin checked prior to each administration
Constipation, abdominal discomfort (sometimes due to other drugs: morphine, morphine-like drugs, anti-emetics)		May happen during treatment	Preventive measures: a large fluid intake, fibre-rich diet, and little physical exercise can be recommended. Laxative and enema may be used if necessary: refer to your doctor.
Nausea, vomiting.		May happen around 5 hours after injection or oral intake	Preventive: your doctor may prescribe you anti-emetics to be taken two hours prior to chemotherapy If vomiting occurs after oral intake, never take another capsule
Neurotoxicity	Sensory symptoms: paresthesia (prickling, pins and needles, numbness...)	Reversible at the end of treatment	If you experience one of these symptoms, inform your doctor.
Alopecia	Moderate, progressive hair loss.	Reversible at the end of treatment.
Reaction on the site of injection (only if IV)	Burning, prickling, oedema, redness or pain around the site of injection.	During the infusion.	Call immediately the chemotherapy nurse who will refer to a specialist.

ADVERSE EFFECTS	HOW DO I KNOW?	CHRONOLOGY	WHAT MUST I DO?
Fever or infection (due to neutropenia, i.e. decreased white blood cells)	fever >38°C other symptoms: shivers, cough, thorethroat, infected, wound, frequency or pain when passing urine, ect.	Risk highest after 7 to 10 days after administration Back to normal within 4 to 5 days	Your doctor has your blood count checked (particulary polynuclear neutrophils) prior to each administration. If you have fever or any of the other symptoms, call your doctor with no delay.
Fatigue (due to anaemia, i.e. decreased haemoglobin in the blood).	loss of energy, of strength difficulty in achieving tasks that used to be easier	May happen during treatment	Your doctor may have your haemoglobin checked prior to each administration
Constipation, abdominal discomfort (sometimes due to other drugs: morphine, morphine-like drugs, anti-emetics)		May happen during treatment	Preventive measures: a large fluid intake, fibre-rich diet, and little physical exercise can be recommended. Laxative and enema may be used if necessary: refer to your doctor.
Nausea, vomiting.		May happen around 5 hours after injection or oral intake	Preventive: your doctor may prescribe you anti-emetics to be taken two hours prior to chemotherapy If vomiting occurs after oral intake, never take another capsule
Neurotoxicity	Sensory symptoms: paresthesia (prickling, pins and needles, numbness...)	Reversible at the end of treatment	If you experience one of these symptoms, inform your doctor.
Alopecia	Moderate, progressive hair loss.	Reversible at the end of treatment.
Reaction on the site of injection (only if IV)	Burning, prickling, oedema, redness or pain around the site of injection.	During the infusion.	Call immediately the chemotherapy nurse who will refer to a specialist.

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